Endocrine Abstracts

Introduction: There is increasing evidence for a role of the CRH/urocortin family in human pregnancy, since they have been implicated both in physiological processes and pathogenesis of diseases such as spontaneous preterm labour. However, little information is available on the presence or function of the CRH/urocortin genes in mouse pregnancy. The study aimed to investigate the expression of CRH, urocortins and their receptors in mouse utero-placental tissues during late preg...

The prokineticins (PK1 and PK2, also known as endocrine gland vascular endothelial growth factor [EG-VEGF] and Bv8 respectively), which bind to two closely homologous G-protein coupled receptors, PKR1 and PKR2, have been identified as novel angiogenic factors in endocrine tissue. However, little information is available on their expression and distribution in the uterus. The objectives of this study were to examine the expression and localisation of prokineticins and their rec...

A 44 year old woman presented in November 2000 with a two week history of headaches, vomiting and blurred vision. Past history consisted of type 2 diabetes and migraine. Initial investigation revealed hyponatraemia (sodium 114 mmol/l) and deranged liver biochemistry. ANA, anti dsDNA, cANCA, pANCA, anti Ro, La, RNP, Scl-70, Jo-1, smooth muscle and mitochondrial antibodies were negative. MRI revealed a 13x18x15mm pituitary mass elevating the optic chaism, without evidence of rec...

A 44 year old woman presented in November 2000 with a two week history of headaches, vomiting and blurred vision. Past history consisted of type 2 diabetes and migraine. Initial investigation revealed hyponatraemia (sodium 114 mmol/l) and deranged liver biochemistry. ANA, anti dsDNA, cANCA, pANCA, anti Ro, La, RNP, Scl-70, Jo-1, smooth muscle and mitochondrial antibodies were negative. MRI revealed a 13x18x15mm pituitary mass elevating the optic chaism, without evidence of rec...

Pituitary gonadotropes (LH and FSH producing cells) are simultaneously exposed to numerous stimuli, which exert multiple signalling pathways that cross-talk with the GnRH receptor (GnRHR). A model downstream effector system is the prostanoid family. Hence, prostanoid receptors and GnRHR might cross-talk and affect the biological responses of the gonadotropes. Here we report the expression of prostaglandin (PG) PGE2 receptors EP1, EP2, EP3 and EP4, the PGF2</sub...